Mitochondrial Cell Biology and Pharmacology Research Lab

Mitochondrial Cell Biology and Pharmacology Research Lab
Major publications

• Campanella M, Kannan B. Mitochondrial sites of contact with the nucleus. J Cell Biol. 2024 Jun 3;223(6):e202305010. doi: 10.1083/jcb.202305010. Epub 2024 Apr 26. PMID: 38669038; PMCID: PMC11046832.
• Singh A, Faccenda D, Campanella M. Pharmacological advances in mitochondrial therapy. EBioMedicine. 2021 Mar;65:103244. doi: 10.1016/j.ebiom.2021.103244. Epub 2021 Feb 26. PMID: 33647769; PMCID: PMC7920826.
• Rigon M, Townley AR and Campanella M. Mitochondria ensure immune surveillance by retro-communication with the nucleus. Cell Met. (2021) doi.org/10.1016/j.cmet.2021.04.013

• Frison M, Strobbe D, Faccenda D, Rigon M, Abeti R, Cash D, England-Rendon BS, Barnes  K, Sadeghian M, Sajic  M, Wells  LA, Giunti  P, Xia  D, Smith  K, Mortiboys H, Turkheimer F and Campanella M. The Translocator Protein (TSPO) is prodromal to mitophagy loss in Neurotoxicity. Mol. Psychiatry (2021). doi.org/10.1038/s41380-021-01050-z
• Desai R, East DA, Hardy L, Crosby J, Rigon M, Faccenda D, Alvarez MS, Singh A, Mainenti M, Kuhlman-Hussey L, Bentham R, Szabadkai G, Zappulli V, Dhoot G, Romano L, Xia D, Hamechar-Brady A, Chapple P, Fleck R, Vizcay-Barrena G, Smith K and Campanella M. Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. Sci Adv 2020 Dec 18;6(51):eabc9955.  doi: 10.1126/sciadv.abc9955. 
• Georgakopoulos ND, Wells G and Campanella M. The Pharmacological Regulation of Cellular Mitophagy. Nat Chem Biol. 2017 Jan 19;13(2):136-146.
• Faccenda D, Nakamura J, Gorini G, Dhoot GK, Piacentini M, Yoshida M, Campanella M. Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1. Cell Rep. 2017 Feb 21;18(8):1869-1883. doi: 10.1016/j.celrep.2017.01.070. PMID: 28228254.
• Gatliff, East D, Crosby J, Abeti R Harvey R, Craigen W, Parker P and Campanella M. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 2014 Dec 2;10(12):2279-96. doi:10.4161/15548627.2014.991665.
• East D, Fagiani F, Crosby J, Bertrand H, Schaap M, Fowkes A, Wells G, and Campanella M. PMI: a novel, ΔΨm independent, Mitophagy Inducer”. Cell Chemical Biology. 2014 Nov 20;21(11):1585-96. doi: 10.1016/j.chembiol.2014.09.019.
• Faccenda D, Tan CH, Seraphim A, Duchen MR & Campanella M. The F1Fo-ATPase endogenous inhibitor IF1 regulates Mitochondrial Commitment to Apoptosis. Cell Death Differ. 2013;20(5):686-97. doi: 10.1038/cdd.2012.163.